Isolation and structure of SCH 351633: a novel hepatitis C virus (HCV) NS3 protease inhibitor from the fungus Penicillium griseofulvum

M Chu; R Mierzwa; L He; A King; M Patel; J Pichardo; A Hart; N Butkiewicz; M S Puar

doi:10.1016/s0960-894x(99)00321-2

Isolation and structure of SCH 351633: a novel hepatitis C virus (HCV) NS3 protease inhibitor from the fungus Penicillium griseofulvum

Bioorg Med Chem Lett. 1999 Jul 19;9(14):1949-52. doi: 10.1016/s0960-894x(99)00321-2.

Authors

M Chu¹, R Mierzwa, L He, A King, M Patel, J Pichardo, A Hart, N Butkiewicz, M S Puar

Affiliation

¹ Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.

PMID: 10450960
DOI: 10.1016/s0960-894x(99)00321-2

Abstract

A new hepatitis C virus (HCV) protease inhibitor designated as Sch 351633 (1) was isolated from the fungus, Penicillium griseofulvum. Structure elucidation of 1 was accomplished by analysis of spectroscopic data, which determined compound 1 to be a bicyclic hemiketal lactone. Compound 1 exhibited inhibitory activity in the HCV protease assay with an IC50 value of 3.8 microg/mL.

MeSH terms

Antiviral Agents / chemistry
Antiviral Agents / pharmacology
Inhibitory Concentration 50
Lactones / chemistry*
Lactones / isolation & purification
Lactones / pharmacology*
Magnetic Resonance Spectroscopy
Molecular Structure
Molecular Weight
Penicillium / chemistry*
Serine Proteinase Inhibitors / chemistry*
Serine Proteinase Inhibitors / isolation & purification
Serine Proteinase Inhibitors / pharmacology*
Viral Nonstructural Proteins / antagonists & inhibitors*

Substances

Antiviral Agents
Lactones
NS3 protein, hepatitis C virus
SCH 351633
Serine Proteinase Inhibitors
Viral Nonstructural Proteins